Coordination Behavior and Biological Activity of Some Transition Metal Complexes with p-nitrophenyl and phenylazo 2, 6 diaminopyridine

doi:10.21608/aunj.2019.220881

Coordination Behavior and Biological Activity of Some Transition Metal Complexes with p-nitrophenyl and phenylazo 2, 6 diaminopyridine

Document Type : Novel Research Articles

10.21608/aunj.2019.220881

Abstract

The objective of this study is to synthesize, characterize and evaluate the biological activity of p-nitrophenylazo and phenylazo 2,6-diaminopyridine and their Co(II)-, Ni(II)- and Cu(II)-chelates. The newly formed metal chelates were characterized by elemental analysis, FT-IR, mass and 1HNMR spectra, thermogravimetric analysis (TGA) and biological activity. The electronic absorption spectra and magnetic susceptibility measurements refer to an octahedral geometry structure of the prepared complexes. The antibacterial and antifungal activities of the ligands and its metal complexes were examined against bacterial species (Staphylococcus aureus, Bacillus subtilis and Escherichia coli) and fungi (Candida albicans). Ampicillin and amphotericin were used as references for antibacterial and antifungal studies. The activity data show that the metal complexes have a conscious biological activity that can be compared with the parent free ligands against bacterial and fungal species.

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