Synthesis and biological activity of some new fused thieno[2,3-b] pyridine derivatives; pyridothienopyrimidinones and pyridothienotriazinones

Document Type : Novel Research Articles

Abstract

3-Amino-4-aryl-5-ethoxycarbonyl-6-methylthieno[2,3-b]pyrindine-2-carboxamides 3a,b were
prepared and reacted with triethyl orthoformate to give pyridothienopyrimidinone derivatives
4a,b. The reaction of compound 3b with potassium ethyl xanthate and/or phenyl isothiocyanate
produced thioxopyridothieno-pyrimidinones 5 and 6 respectively. Diazotisation of compounds
3a,b led to the formation of 9-aryl-8-ethoxycarbonyl-7-methylpyrido[3’,2’:4,5]thieno[3,2-d]
[1,2,3]triazine-4(3H)-ones (7a,b). Compounds 5, 6 and 7a,b underwent some reactions to
furnish other new pyridothienopyrimidinones 8, 9a,b and pyridothienotriazinones 10-13a,b.
The structural formulas of all newly synthesized compounds were confirmed by elemental and
spectral analyses. Also, the biological activity of fifteen compounds as antibacterial and
antifungal agents were studied.

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