Therapeutic potential of Bee gomogenat against testicular damage in a streptozotocin- induced type I diabetic mouse model

Document Type : Novel Research Articles

Authors

1 Zoology Department, Faculty of Science, Assiut University

2 Pathology and clinical pathology Department, Faculty of Veterinary Medicine, Assiut University

3 Professor of Immunology Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt

Abstract

Diabetes Mellitus (DM) is a metabolic disorder that has serious effects for male fertility. Additionally, DM mediates impairment of spermatogenesis; decrease in count of sperm, viability, and motility; and apoptosis in both somatic and germ cells. Our study aimed to investigate the dietary effect of bee gomogenat (BG) supplementation on the architecture of testis in mouse model of streptozotocin (STZ)-induced type 1 diabetes (TID). We used three animal groups: control non-diabetic, diabetic, and BG-treated diabetic mice. STZ-induced diabetes was associated with pathological alterations in the architecture of the testis, decreased distribution of YAP+ Leydig cells in testis sections and decreased level of testosterone. Furthermore, diabetic mice showed perturbed alteration in the expression of PPAR-γ, Nrf2 and 3β-HSD in testis as compared to control animals. Interestingly, supplementation of diabetic mice with BG mediated an improvement the architecture of testis, restored the distribution of YAP+ Leydig cells and the testosterone level. Furthermore, Treatment of diabetic mice with BG significantly restored the expression levels of PPAR-γ, Nrf2 and 3β-HSD nearly to control animals.
Conclusion: Our data revealed, for the first time, the beneficial impacts of BG supplementation on the architecture and functions of testis during T1D.

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Assiut University Journal of Multidisciplinary Scientific Research
Volume 1, Issue 1 - Serial Number 1
The 7 th Conference for Young Scientists in Basic and Applied Sciences, May 10-11th, 2022.
2022
Pages 17-37

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