Nanosized Aluminum Metal-Organic Framework Encapsulating Edaravone Drug: Synthesis and Characterization.

Osman, Rabab Mohamed; El-Fadl, A. Abu; Darwish, Abdelhamid; Sayed, Ahmed

doi:10.21608/aunj.2024.329999.1097

Nanosized Aluminum Metal-Organic Framework Encapsulating Edaravone Drug: Synthesis and Characterization.

Document Type : Novel Research Articles

Authors

¹ Physics, faculty of science, Assiut university, Assiut

² Assuit University, faculty of Science,departement of Physics

³ Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt

10.21608/aunj.2024.329999.1097

Abstract

The hydro solvothermal method was employed to synthesize nano porous aluminum metal organic framework (Al-MOF) nanoparticles (NPs), which were utilized as a matrix for the pharmaceutical delivery of Edaravone (Ed). The drug encapsulation efficiency (EE) and loading capacity (LC) indicate the potential of Al metal organic framework NPs as effective drug delivery vehicles. The structural and functional properties of both the Al metal organic framework NPs and Ed-loaded Al metal organic framework NPs (Ed@Al-MOF) were characterized using several techniques, including ultraviolet-visible (UV-Vis) spectroscopy, Transmission Electron Microscopy (TEM) for morphological analysis, X-ray diffractometry (XRD), and Fourier-transform infrared (FTIR) spectroscopy. Additionally, the thermal stability of the Ed@Al metal organic framework NPs was evaluated through thermogravimetric analysis (TGA). These promising results underscore the potential of Al metal organic framework NPs as a viable platform for drug delivery, necessitating further investigations to confirm the applicability of Ed@Al metal organic framework NPs in therapeutic contexts.

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